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英国牛津大学结构生物学专业博士后职位
Applications are invited for two postdoctoral positions in a new programme, funded by Leukaemia and Lymphoma Research, to discover and develop small molecule inhibitors of oncogenic proteins for the treatment of leukaemia/lymphoma. The posts will be available for 3 years in the laboratory of Professor Terry Rabbitts: http://www.imm.ox.ac.uk/wimm-research/molhaem/terry_rabbitts.
The aim of this project is to discover small-molecule drugs that inhibit protein-protein interactions involving transcription factor multi-protein complexes in leukaemia and lymphoma. The approach will involve novel strategies using single domain antibody fragments and peptide aptamers, as tools for the identification of drug-like molecules to lead the development for treatment of cancer.
The programme involves structural determination of leukaemia proteins together with screening and characterisation of small molecule inhibitors of protein-protein interactions. In particular, the project will use the structure of single antibody domains as templates for drug lead development.
You will have a PhD in structural biology, experience with recombinant protein production purification and with solving structures using X-ray diffraction. Experience with surface plasmon resonance, AlphaScreen and other methods for small molecule screening and NMR are desirable.
Informal enquiries may be made to Professor Terry Rabbitts at terence.rabbitts@imm.ox.ac.uk.
You will be required to upload a CV and supporting statement as part of your online application.
The closing date for this position is noon on Friday 8 February 2013.
Please quote reference 106000 in all correspondence. |
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