Employer: The Wellcome Trust Sanger Institute Location: Hinxton, Cambridge, United Kingdom Type: Postdoctoral Posted: October 11, 2011 Expires: November 09, 2011 Jobs by tag(s): the wellcome trust sanger institute postdoctoral postdoc biomedical sciences computational genomics genetics bioinformatics genetic variation personalized medicine phenotype Requisition number: 81018 job description The Wellcome Trust Sanger Institute Postdoctoral Position in Computational Genomics
The Wellcome Trust Sanger Institute is a world leader in genomic research, with an expanding scientific programme dedicated to understanding gene function in health & disease.
A postdoctoral position in Computational Genomics is available at the Wellcome Trust Sanger Institute under the leadership of Dr Daniel Gaffney. The project will focus on understanding the role of regulatory variation in the functional architecture of complex traits, in particular susceptibility to autoimmune disorders, using HapMap cell lines and human pluripotent stem cells as model systems. The post-holder will develop computational methods to analyze and integrate a wide variety of high-throughput sequencing data, with the goal of understanding how variation in gene regulation and expression affects complex phenotypes and disease susceptibility. Our lab combines computational and experimental methods to address research questions and the successful candidate will have the opportunity to interact closely with wet-lab researchers and have access to novel high-throughput, next generation sequencing data.
We welcome candidates with a background in Biology and strong quantitative skills. Candidates from Physics, Statistics or Computer Science with strong interests in computational biology and/or population genetics are also encouraged to apply. Excellent programming skills, experience with very large data sets and an ability to work as part of a team are essential.
Essential Skills
PhD in a relevant subject area (Computational Biology, Population Genetics/Genomics, Computer Science, Physics) Excellent programming skills (C, C++, Perl, Python, Ruby) Strong statistical and quantitative skills Familiarity with statistical modeling and software Ability to communicate ideas and results effectively and to publish results in high-impact journals Ability to work well with other team members Ability to work to tight deadlines
Ideal Skills
Experience with analysis of -omics data sets Previous experience with genetics of gene regulation, QTL analysis
Other information
Although genetic variation in gene regulation is thought to play an important role in evolution and disease, the pathway from regulatory mutation, via gene expression to phenotype is still poorly understood. Understanding this pathway will be an essential component in the application of genomics to personalized medicine. The Sanger Centre offers a world-class academic environment, access to cutting edge sequencing facilities and extensive expertise in genome analysis and human genetics. As such, we are in a prime position to begin to address some of these fundamental questions. The ultimate goal of our lab is to be able to predict the impact of new mutations on gene regulation and to understand how such changes impact phenotype. To achieve this, we combine of sequence and genome analysis, comparative genomics and population level, expression QTL-mapping.
Postdoctoral Fellows are typically in their first or second postdoctoral position as part of a period of early career research training. Successful applicant(s) who have submitted their PhD thesis and are awaiting their PhD award to be confirmed will be placed on a transitional pay point, currently £26,103. On confirmation applicants will be moved on to the pay scale above.
This position is initially for a fixed term of 3 years. For further information please contact Daniel Gaffney on dg13@sanger.ac.uk or visit: http://www.sanger.ac.uk/research/faculty/dgaffney/.
The closing date for applications is 9th November 2011 Salary Range: £28280 to £34778 per annum dependent on experience
Benefits
The Institute has excellent purpose built facilities on the Genome Campus, Hinxton on the outskirts of Cambridge. We offer a comprehensive range of benefits including a final salary pension scheme and excellent on-site facilities. Further details can be found on our website https://jobs.sanger.ac.uk
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